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Vicodin is an opioid pain medication that contains a combination of hydrocodone and acetaminophen. Hydrocodone is an opioid substance that affects the brain to relieve pain. Acetaminophen is a non-opioid and less potent pain reliever that increases the effects of hydrocodone. This drug is helpful in the treatment of severe to moderate pain. Doctors might also prescribe this medicine as a cough suppressant in adults.