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Smoking and substance use can undermine the effectiveness of Tadaflo 5mg by constricting blood vessels and reducing blood flow. Quitting smoking and avoiding recreational drugs can lead to better outcomes for individuals with ED. Overall health and any underlying medical conditions should also be taken into account when using Tadaflo 5 Mg. Managing chronic conditions such as diabetes, hypertension, or high cholesterol can help improve erectile function and enhance the effectiveness of the medication.